With John Terry beginning a four-game suspension, Gary Cahill comes in to partner David Luiz in central defence.
Frank Lampard, meanwhile, having recovered from a calf injury, starts on the bench, with Ramires playing alongside John Mikel Obi as the two deep-lying midfielders.
Fernando Torres starts up front, while Daniel Sturridge is fit again and is named as one of our substitutes.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1 Petr Cech
2 Branislav Ivanovic
4 David Luiz
26 Gary Cahill
3 Ashley Cole
12 John Mikel Obi
7 Ramires (c)
10 Juan Mata
17 Eden Hazard
9 Fernando Torres
Substitutes: 22 Ross Turnbull, 28 Cesar Aspilicueta, 34 Ryan Bertrand, 6 Oriol Romeu, 8 Frank Lampard, 13 Victor Moses, 23 Sturridge.
Tottenham are expected to line up in the following 4-2-3-1 formation:
Friedel; Walker, Gallas (c), Caulker, Vertonghen; Sandro, Huddlestone; Lennon, Dempsey, Sigurdsson; Defoe.
Substitutes: Lloris, Dawson, Livermore, Naughton, Falque, Townsend, Adebayor.
The referee is Mike Dean.
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