John Terry, Frank Lampard and Ashley Cole return to the starting line-up with David Luiz playing his 50th Chelsea game of the season in midfield.
Branislav Ivanovic will partner Terry in central defence and Eden Hazard takes on the 'No. 10' role in support of Fernando Torres, with Ramires and Victor Moses the wide players.
Basel are unchanged from the second leg of their quarter-final win over Tottenham.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1 Petr Cech
28 Cesar Azpilicueta
26 John Terry (c)
2 Branislav Ivanovic
3 Ashley Cole
4 David Luiz
8 Frank Lampard
17 Eden Hazard
13 Victor Moses
9 Fernando Torres
Substitutes: 22 Ross Turnbull, 24 Gary Cahill, 34 Ryan Bertrand, 12 John Mikel Obi, 11 Oscar, 10 Juan Mata, 30 Yossi Benayoun.
Basel are expected to line up in the following 4-2-3-1 formation:
Sommer; P Degen, Schär, Dragovic, Park Joo Ho; Elneny, F Frei; Salah, Serey Die, Stocker; Streller (c).
Substitutues: Vailati ,Marcelo Diaz, Sauro, D Degen, Zoua, Cabral, Steinhofer.
The referee is Pavel Kralovec from Czech Republic.
Follow the game via our Live Matches from 7.35pm (UK time).