Juventus need a win while Chelsea must avoid defeat. We look at which factors might determine which side achieves their aim tonight.
Robbie Di Matteo omitted five regulars from the start at West Brom following the latest air miles extravaganza of international friendlies and ahead of this season-defining game in Group E.
He was disappointed with the performance, especially at either end of the field, and hinted at changes in personnel and approach. The grey of November has replaced the bright colours of autumn and the former Lazio man says he may explore a more defensive line-up to stem the concession of goals.
A draw would suit the Blues tonight, but without the likes of John Terry and Frank Lampard, does the Italian have the personnel to go catenaccio and lock Juve out? Having Ashley Cole fit again will certainly help.
If Antonio Conte's Serie A leaders have a weakness it is the lack of a prolific goalscorer. Fabio Quagliarella and Sebastian Giovinco have 10 between them in the league. Chelsea have a similiar problem, but like the Blues, Juve benefit from a midfield threat, especially Arturo Vidal.
Just six of the Blues' 24 Premier League goals have been scored by forwards; fewer than the seven netted by defenders and 11 derived from midfield. Set plays may well be an important asset to the Londoners this evening.
The defending champions' top scorer in this competition so far is Oscar. He played a key role in the reverse of this fixture at Stamford Bridge. Until he was stamped out of the game by Leonardo Bonucci (a foul that bizarrely went entirely unpunished) the youngster was deputed to track Juve playmaker Andrea Pirlo deep in the Italians' own half, and to steal possession where possible.
The Brazilian topped that by hitting two goals, one a sensational strike that is a candidate for goal of the season. Pirlo, 33, has been well rested by club and country in recent weeks ahead of this match.
One Chelsea forward who made his mark in the game against Shakhtar was Victor Moses. The Nigerian's first goal in Europe's elite competition showed that he can provide the forceful individual interventions that have been a hallmark of our African players in this competition: we think of Michael Essien against Barcelona or Valencia, Didier Drogba against so many - not least Munich in last season's final.
Chelsea have bucked the trend of poor domestic form in this competition before. We must hope they manage the same in northern Italy tonight.
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The Blues have topped our group in seven of our last nine Champions League campaigns. We have never failed to progress to the knockout stage.
Chelsea have won eight and lost six of our last 21 away games in the Champions League. Last term we failed to win any of our away group matches having taken the lead in all three. We achieved draws at Valencia and Genk and fell to a last-minute winner at Bayer Leverkusen.
We have scored in our last 18 Champions League matches since we lost 0-1 to Man Utd in the 2010/11 quarter-final at Stamford Bridge.
Our record in Italy is only one win in 11 matches, drawing five and losing five.
|Chelsea's away record against Italian teams|
|1965/66||Roma||D 0-0||Inter-Cities Fairs Cup first round|
|1965/66||AC Milan||L 1-2||Inter-Cities Fairs Cup third round|
|1965/66||AC Milan||D 1-1||Inter-Cities Fairs Cup third round play-off|
|1997/98||Vicenza||L 0-1||European Cup Winners' Cup semi-final|
|1999/00||AC Milan||D 1-1||Champions League first group stage|
|1999/00||Lazio||D 0-0||Champions League second group stage|
|2003/04||Lazio||W 4-0||Champions League group stage|
|2008/09||Roma||L 1-3||Champions League group stage|
|2008/09||Juventus||D 2-2||Champions League round of 16|
|2009/10||Inter||L 1-2||Champions League round of 16|
|2011/12||Napoli||L 1-3||Champions League round of 16|
Chelsea's last ten years in Europe
2002/03 - UEFA Cup - first round
2003/04 - Champions League - semi-final
2004/05 - Champions League - semi-final
2005/06 - Champions League - round of 16
2006/07 - Champions League - semi-final
2007/08 - Champions League - runners-up
2008/09 - Champions League - semi-final
2009/10 - Champions League - round of 16
2010/11 - Champions League - quarter-final
2011/12 - Champions League - winners
|Last six results|
|Oct 28||Manchester United (h)||L 2-3|
|Oct 31||Manchester United (League Cup h)||W 5-4 aet|
|Nov 3||Swansea (a)||D 1-1|
|Nov 7||Shakhtar Donetsk (Champions League h)||W 3-2|
|Nov 11||Liverpool (h)||D 1-1|
|Nov 17||West Brom (a)||L 1-2|
Scorers Mata 7, Torres 7, Cahill 5, Hazard 4 (2 pens), Oscar 4, Ivanovic 3, Lampard 3 (2 pens), Moses 3, Ramires 3, Bertrand 2, D Luiz 2 (1 pen), Sturridge 2, Cole 1, Romeu 1 (pen), Terry 1. Total 48.
|Chelsea's next three games|
|Sun 25 Nov||Manchester City home||4pm|
|Wed 28 Nov||Fulham home||7.45pm|
|Sat 1 Dec||West Ham away||12.45pm|
We need two more goals for the half century for the season. Tonight is our 21st match.
28 league titles, last in 2012
9 Italian Cups, last in 1995
5 Italian Super Cups, last in 2012
2 European Cups, last in 1996
1 European Cup Winners' Cup in 1984
3 UEFA Cups, last in 1993
2 UEFA Super Cups, last in 1996
2 Intercontinental Cup, last in 1996
Juventus have been crowned European Champions on two occasions - in 1984/85 against Liverpool and 1995/96 against Ajax on penalties. They have been runners-up five times; 1973 v Ajax, 1983 v Hamburg, 1997 v Borussia Dortmund, 1998 v Real Madrid and AC Milan with Andriy Shevchenko on penalties in 2003.
|Last ten league seasons|
In winning Serie A last season Juventus remained unbeaten. Their only defeat came in the Coppa Italia final against Napoli.
Their 49-game unbeaten league run, stretching back to May 2011, ended on the 3 November at home to Inter Milan. It fell short of the all-time Italian top-flight record of 58 set in the early nineties by an AC Milan side that included Carlo Ancelotti and Ruud Gullit.
Juve's win against Nordsjaelland on Matchday Four ended a run of nine successive draws in European competition. They came behind in all the first three of this season's group matches to secure a point.
Juve have only beaten English opposition at home once in six attempts over the last 10 years.
Their overall record against English teams is 15 wins, 13 draws and 15 defeats.
Saturday's goalless draw against Lazio maintained their four-point lead at the top of Serie A.
Their home domestic and European record this season is six wins, two draws and one defeat.
Their all-time European Cup/Champions League record is played 205, won 101, drawn 52, lost 52.
|Juve's last 10 away games against English teams in Europe|
|1997/98||Man Utd||W 1-0||Champions League group stage|
|1998/99||Man Utd||L 2-3||Champions League semi-final|
|2001/02||Arsenal||W 1-0||Champions League second group stage|
|2002/03||Newcastle||W 2-0||Champions League first group stage|
|2002/03||Man Utd||L 0-3||Champions League second group stage|
|2004/05||Liverpool||D 0-0||Champions League quarter-final|
|2005/06||Arsenal||D 0-0||Champions League quarter-final|
|2008/09||Chelsea||D 2-2||Champions League round of 16|
|2009/10||Fulham||W 3-1||Europa League round of 16|
|2010/11||Man City||D 1-1||Europa League group stage|
Ten-year European record
2002/03 - Champions League runners-up
2003/04 - Champions League round of 16
2004/05 - Champions League quarter finals
2005/06 - Champions League quarter finals
2006/07 - Did not qualify
2007/08 - Did not qualify
2008/09 - Champions League round of 16
2009/10 - Europa League round of 16 having transferred from the Champions League group stage
2010/11 - Europa League group stage
2011/12 - Did not qualify
|Champions League results|
|Sep 19||Chelsea (a)||D 2-2|
|Oct 2||Shakhtar Donetsk (h)||D 1-1|
|Oct 23||FC Nordsjaelland (a)||D 1-1|
|Oct 23||FC Nordsjaelland (h)||W 4-0|
Champions League scorers
Quagliarella 2, Vidal 2, Bonucci 1, Giovinco 1, Marchisio 1, Vučinić 1.
|Last six domestic results|
|Oct 20||Napoli (h)||W 2-0|
|Oct 28||Catania (a)||W 1-0|
|Oct 31||Bologna (h)||W 2-1|
|Nov 3||Inter (h)||L 1-3|
|Nov 10||Pescara (a)||W 6-1|
|Nov 17||Lazio (h)||D 0-0|
Serie A scorers
Quagliarella 6, Vidal 5 (2 pens), Giovinco 4, Pirlo 3, Asamoah 2, Pogba 2, Vučinić 2 (1 pen), Cáceres 1, Giaccherini 1, Lichtsteiner 1, Marchisio 1, Matri 1. Total 29.
|Serie A top five|
THE MAN IN THE MIDDLE
Referee Cüneyt Çakır, his two assistant referees and two additional assistants are all from Turkey. Chelsea fans will have fond memories of two games he handled: the 4-1 beating of Spartak Moscow in 2010 and especially the epic 2-2 draw away to Barcelona last season.
His sole Juventus game before tonight was a 2-1 Europa League qualifier win in August 2010.
Juventus manager Antonio Conte is currently banned over alleged match-fixing violations.
There are no other suspensions.
Champions League bookings list
Players receive a one-match suspension for collecting three and five yellow cards
Juventus (7): Chiellini 2, Marchisio 2, Lichtsteiner 1, Pogba 1, Vidal 1.
Chelsea (4): D Luiz 2, Cole 1, Ramires 1