Eden Hazard makes his first Premier League start since the game against Manchester United and Alvaro Morata comes back into the side to lead the line.
As expected, Maurizio Sarri makes significant changes to the side which started against BATE Borisov on Thursday.
The regular Premier League back four all are all restored to the starting line-up, while Mateo Kovacic is given the nod ahead of Ross Barkley, who starts on the bench against his former club.
Morata, who didn't travel to Belarus, starts up front, flanked by Hazard and Willian.
For Everton, Richarlison has been passed fit to start while Kurt Zouma, on loan from the Blues, is ineligible to feature.
Chelsea: Kepa; Azpilicueta (c), Rudiger, David Luiz, Alonso; Kante, Jorginho, Kovacic; Willian, Morata, Hazard.
Subs: Caballero, Zappacosta, Christensen, Fabregas, Barkley, Pedro, Giroud.
Everton: Pickford, Coleman (c), Keane, Mina, Digne, Gomes, Gueye, Walcott, Sigurdsson, Bernard, Richarlison.
Subs: Stekelenburg, Jagielka, Baines, Davies, Lookman, Calvert-Lewin, Tosun.
Today's referee is Kevin Friend.