Maurizio Sarri makes five changes from the side which beat Fulham three days ago.
Andreas Christensen starts for the first time in the Premier League season in the one change to the defence.
Cesc Fabregas and Sunday goalscorer Ruben Loftus-Cheek come into midfield and upfront, Alvaro Morata and Willian join Eden Hazard.
One of Wolves four changes is enforced due to suspension for Ruben Neves. Ryan Bennett, Morgan Gibbs-White, Diogo Jota and Raul Jiminez all come in.
Chelsea: Kepa; Azpilicueta (c), Rudiger, Christensen, Alonso; Kante, Fabregas, Loftus-Cheek; Willian, Morata, Hazard.
Subs: Caballero, Zappacosta, David Luiz, Jorginho, Kovacic, Pedro, Giroud.
Wolves: Rui Patricio; Bennett, Coady (c), Boly; Doherty, Saiss, Moutinho, Vinagre; Gibbs-White, Jiminez, Jota.
Subs: Ruddy, Hause, Dendoncker, Traore, Cavaleiro, Bonatini, Costa.
Today's referee is Jon Moss.