David Luiz, Jorginho, Mateo Kovacic and Pedro come into the starting line-up for today's game.
Maurizio Sarri makes four changes to the side which started against Wolves on Wednesday, with David Luiz replacing Andreas Christensen in the back four.
In midfield, Jorginho and Kovacic start, Cesc Fabregas and Ruben Loftus-Cheek dropping down to the bench, and further forward Pedro, Eden Hazard and Willian form the attacking trio.
Having missed the last couple of matches through injury, Ross Barkley is named among the subs, along with Emerson Palmieri.
Sergio Aguero is out injured for the visitors.
Kepa, Azpilicueta (c), Rudiger, David Luiz, Alonso, Kante, Jorginho, Kovacic, Pedro, Hazard, Willian.
Subs: Caballero, Emerson, Christensen, Fabregas, Barkley, Loftus-Cheek, Giroud.
Ederson, Walker, Stones, Laporte, Delph, D Silva (c), Fernandinho, B Silva, Mahrez, Sane, Sterling.
Subs: Muric, Danilo, Kompany, Otamendi, Gundogan, Foden, Jesus.
Today's referee is Michael Oliver.