Kepa Arrizabalaga returns to the Chelsea starting line-up.
The goalie, who was dropped for the win against Tottenham on Wednesday, plays behind a defence showing two changes - Andreas Christensen and Emerson in for David Luiz and Marcos Alonso.
In midfield, Ross Barkley is preferred to Mateo Kovacic, and Willian takes over from Pedro alongside Gonzalo Higuain and Eden Hazard in attack.
Fulham caretaker boss Scott Parker makes one change as he names his first line-up. Ryan Sessegnon replaces Andre-Frank Zambo Anguissa. Former Blue Andre Schurrle is absent due to illness.
Chelsea: Kepa; Azpilicueta (c), Rudiger, Christensen, Emerson; Kante, Jorginho, Barkley; Willian, Higuain, Hazard.
Subs: Caballero, David Luiz, Kovacic, Loftus-Cheek, Hudson-Odoi, Pedro, Giroud.
Fulham: Rico; Odoi, Nordtveit, Ream, Bryan; Chambers, McDonald, Sessegnon; Cairney (c); Babel; Mitrovic.
Subs: Fabri, Christie, Seri, Le Marchand, Anguissa, Ayite, Vietto.
Today's referee is Graham Scott.
Chelsea have kept three successive clean sheets in all competitions and conceded just three shots on target in those games.
The Blues are looking to avoid four successive away league defeats for the first time since a run of five between October and December 2000.
Chelsea have lost two of our four away London derby matches this season. We last lost three away London derbies in a league campaign back in 2001/02.
Cesar Azpilicueta and N’Golo Kante have started every Premier League game this season.
Twenty-one per cent of the goals Chelsea have conceded in the Premier League this season have come from free-kick situations (6/29) – the highest percentage in the division.
Half of Pedro’s eight Premier League goals this season have come in London derbies.
Fulham have lost seven of their last eight Premier League games.
Fifteen of Fulham’s 17 points this season have come at Craven Cottage.
Fulham have conceded 63 Premier League goals this season, more than any other side in Europe’s top five leagues.
Fulham have conceded more than once in 22 Premier League games this season, including all eight since the turn of the year.