Toni Rudiger and Marcos Alonso are both back from injury and start.
Andreas Christensen and Emerson are the players replaced. In midfield, Mateo Kovacic is preferred to Ruben Loftus-Cheek and up front, Willian comes in for Callum Hudson-Odoi whose season ended during our Monday night match at home to Burnley. N'Golo Kante has been passed fit to play having come off in that game with a bang to the ribs.
Kepa Arrizabalaga in goal makes his 50th Chelsea appearance.
Man United are much changed from their derby defeat midweek. Former Blues Nemanja Matic, Juan Mata and Romelu Lukaku are added to their line-up and there is a return for Ander Herrera in midfield. Eric Bailly is another change in defence.
Chelsea (4-3-3): Arrizabalaga; Azpilicueta (c), Rudiger, David Luiz, Alonso; Kante, Jorginho, Kovacic; Willian, Higuain, Hazard.
Subs Caballero, Zappacosta, Christensen, Barkley, Loftus-Cheek, Pedro, Giroud.
Man United: De Gea; Young (c), Bailly, Lindelof, Shaw; Herrera, Matic, Pogba; Mata; Rashford, Lukaku.
Subs Romero, Rojo, Pereira, Darmian, McTominay, Sanchez, Martial.
The referee is Martin Atkinson.
Chelsea have won more Premier League games against Manchester United than any other side have in the competition (18).
Manchester United are unbeaten in the last five Premier League meetings at home against Chelsea, winning the last two.
The Red Devils have not beaten the Blues in three consecutive top-flight games at Old Trafford since January 1957 when Matt Busby was in charge.
Chelsea’s last victory at Old Trafford was in May 2013 when Juan Mata’s 87th-minute goal secured all three points.
We have lost our last six Premier League away games against fellow ‘big six’ opponents, including all four this season by an aggregate score of 1-13. Our last away win was nine games ago against Tottenham at Wembley in August 2017.
Our recent away league record is five defeats without scoring and two wins in our last seven.
We have last and drawn our previous two league games. Chelsea have not gone three Premier League games without a win since September 2016. Following that previous run, the Blues went on a 13-game winning streak in the competition.
Thirty-two per cent of Chelsea’s goals in the Premier League this season have been scored in the final 15 minutes, including Ross Barkley's late equaliser when we met Man Utd at the Bridge earlier this season.