Maurizio Sarri makes four changes from the side that began in Germany on Thursday night.
Eden Hazard returns to the starting line-up, as does Gonzalo Higuain with Pedro, our goalscorer against Eintracht Frankfurt, retained as the other member of the front three.
Mateo Kovacic comes in for Ruben Loftus-Cheek in midfield and Marcos Alonso takes over from Emerson Palmieri at left-back. David Luiz makes his 150th Premier League start for the Blues.
For Watford, former Chelsea man Nathaniel Chalobah comes into their midfield for injured Etienne Capoue. Troy Deeney, back from suspension, is preferred to Andre Gray in attack.
Chelsea (4-3-3): Arrizabalaga; Azpilicueta (c), Christensen, David Luiz, Alonso; Kante, Jorginho, Kovacic; Pedro, Higuain, Hazard.
Subs Caballero, Zappacosta, Cahill, Barkley, Loftus-Cheek, Willian, Giroud.
Watford (4-2-2-2): Foster; Femenia, Mariappa, Cathcart, Holebas; Doucoure, Chalobah; Hughes, Pereyra; Deulofeu, Deeney
Subs Gomes, Janmaat, Masina, Kabasele, Cleverley, Success, Gray.
The referee is Paul Tierney
Chelsea are unbeaten in 11 home matches against Watford in all competitions (seven wins, four draws) since a 1-5 defeat on the final day of the 1985/86 season. Gordon Durie made his debut in that match and a young Les Fridge made his only appearance in goal in front of a crowd of 12,017.
In our five games at Stamford Bridge between Chelsea and Watford in the Premier League there have been 24 goals scored (Chelsea 16, Watford 8) at an average of 5.25 per game.
Chelsea have won 11 of our past 14 home matches in all competitions, with our only defeat in that time coming against Manchester United in the FA Cup fifth round in February.
Maurizio Sarri’s side have lost one Premier League home game so far this season (Leicester in December), and have kept eight clean sheets in our past 12 matches at Stamford Bridge conceding just five goals in total during this period.
The Blues have lost one of our past 21 home games in the Premier League (12 wins, eight draws).
Chelsea have not lost our last home league game of the season since the 2001/02 campaign (1-3 v Aston Villa), with the Blues winning 10 and drawing six since then.
We have kept 14 clean sheets in the Premier League this term, only Liverpool (20) and Man City (19) have recorded more.
Chelsea have conceded fewer goals in the final 15 minutes than any other Premier League team this season (four).
Eden Hazard has scored in 50 home games without ending on the losing side, winning 42 and drawing eight.
Since their return to the Premier League in 2015, Watford have scored more Premier League goals against Chelsea than they have against any other side (13). They’ve also scored more goals at Stamford Bridge (seven) than any other visiting side over the past four seasons.
Watford are looking to win consecutive away league games for the first time since a run of three in September 2017.
The Hornets have gone 10 Premier League games without a clean sheet, the current longest run in the division.