Andreas Christensen starts on the bench so Cesar Azpilicueta is expected to play in the centre-back position where he ended Thursday's Europa League game.
Azpilicueta's selection means he is the one Chelsea ever-present in the Premier League this season.
Willy Caballero is given a game in goal and Ross Barkley replaces Mateo Kovacic in midfield. With Eden Hazard also among the subs, Pedro and Willian flank Gonzalo Higuain in attack.
Eighteen-year-old defender Marc Guehi is named on the bench.
Leicester are unchanged from their defeat at Man City.
Chelsea (4-3-3): Caballero; Zappacosta, Azpilicueta (c), David Luiz, Alonso; Barkley, Jorginho, Loftus-Cheek; Pedro, Higuain, Willian.
Subs Arrizabalaga, Emerson, Guehi, Christensen, Kovacic, Hazard, Giroud.
Leicester: Schmeichel (c); Pereira, Evans, Maguire, Chilwell; Albrighton, Tielemans, Ndidi, Choudhury, Maddison; Vardy.
Subs Ward, Morgan, Simpson, Gray, Barnes, Okazaki, Iheanacho.
The referee is Anthony Taylor.
Chelsea are looking to avoid Leicester completing the league double over us for the first time since the 2000/01 campaign. The Foxes won the reverse fixture at Stamford Bridge 1-0.
Jamie Vardy has scored each of Leicester’s last three goals against Chelsea in all competitions, including the winner in the reverse fixture in December.
Chelsea have won seven of our past eight away games at Leicester in all competitions, with the exception being a 1-2 defeat in the Foxes’ title winning campaign of 2015/16.
Leicester have not kept a clean sheet at home to Chelsea in any competition since February 1998 (2-0), conceding in each of their last 11 home games against us (29 goals – an average of 2.6 per game).
Chelsea are guaranteed a top four finish in the Premier League this season – since four English clubs could qualify for the Champions League in 2001/02, only Arsenal (15) have finished in these places more often than the Blues (14).
The Blues have kept 15 clean sheets in the Premier League this term, only Liverpool (20) and Man City (20) have recorded more.
We have kept just one clean sheet in our last 13 away league games, conceding in each of their last eight. We last conceded in nine consecutive Premier League games on the road in February 2001.
Chelsea have lost one of our last seven games in the Premier League, winning four and drawing two. The defeat was at Anfield in April.
We have conceded the fewest Premier League goals in the final 15 minutes of matches this season (4).
Eden Hazard has been directly involved in more Premier League goals than any other player this season (16 goals, 15 assists).