Gonzalo Higuain is handed his Premier League debut for the Blues while Emerson Palmieri makes his first league start of the season.
Having started against Sheffield Wednesday on Sunday, Higuain is once again selected to lead the line this evening, and he is joined in attack by Eden Hazard and Pedro, who return to the side.
David Luiz comes back in to partner Toni Rudiger in central defence while Emerson, impressive against Tottenham in the Carabao Cup last week, starts at left-back.
Former Chelsea defender Nathan Ake starts for the hosts, while both Asmir Begovic and Dominic Solanke are named among the Bournemouth subs.
Kepa; Azpilicueta (c), Rudiger, David Luiz, Emerson; Kante, Jorginho, Kovacic; Pedro, Higuain, Hazard.
Subs: Caballero, Christensen, Alonso, Barkley, Loftus-Cheek, Willian, Giroud.
Boruc, Clyne, Cook, Gosling, Ake, Surman (c), Smith, Stanislas, Brooks, Fraser, King.
Subs: Begovic, Mousset, Ibe, Daniels, Rico, Solanke, Mepham.
Tonight’s referee is Roger East
Maurizio Sarri’s side have the fourth-best away record in the Premier League this season, winning 22 points from a possible 33.
Eden Hazard has notched seven goals in his last eight games against Bournemouth in all competitions.
Willian’s penalty against Sheffield Wednesday was his 50th for Chelsea in all competitions.
Cesar Azpilicueta captained Chelsea for the 50th occasion against Sheffield Wednesday.
Ruben Loftus-Cheek made his 50th appearance in all competitions for the Blues on Sunday against the Owls.