Willy Caballero starts in goal and there are also places in the side for teenagers Ethan Ampadu and Callum Hudson-Odoi.
The latter of those and Ruben Loftus-Cheek are expected to flank Alvaro Morata in attack.
The defence has Andreas Christensen and David Luiz at its heart with Davide Zappacosta and Emerson Palmieri at full-back, while Cesc Fabregas and Ross Barkley bring experience to a midfield also containing Ampadu.
The bench is strong.
Forest make four changes including one for goalkeeper Costel Pantilimon who is replaced by Luke Steele.
Chelsea: Caballero; Zappacosta, Christensen, David Luiz, Emerson; Ampadu, Fabregas (c), Barkley; Loftus-Cheek, Morata, Hudson-Odoi.
Subs: Kepa, Azpilicueta, Rudiger, Jorginho, Kante, Moses, Hazard.
Forest: Steele; Janko, Yacob, Fox (c), Darikwa, Guedioura, Colback, Cash, Carvalho, Osborn, Murphy.
Subs: Smiith, Robinson, Yates, Lolley, Dias, Appiah, Ahmedhodzic.
The referee is: Andrew Madley