Youngsters Andreas Christensen and Callum Hudson-Odoi are both handed starts.
Willian has recovered from injury and is also in the side. There is no Alvaro Morata due to a minor hamstring problem in training this morning. Eden Hazard will be at the centre of the attack. Christensen plays alongside Toni Rudiger in central defence.
Olivier Giroud, Pedro and Mateo Kovacic have recovered from injury or illness sufficiently to be on the bench.
Tottenham name Paulo Gazzaniga in goal with Hugo Lloris among their subs.
Chelsea: Kepa; Azpilicueta (c), Rudiger, Christensen, Alonso; Kante, Jorginho, Barkley; Hudson-Odoi., Hazard, Willian.
Subs: Caballero, David Luiz, Zappacosta, Ampadu, Kovacic, Pedro, Giroud.
Tottenham: Gazzaniga; Trippier, Alderweireld, Sanchez, Rose; Sissoko, Winks; Alli, Eriksen, Son; Kane (c).
Subs: Lloris, Walker-Peters, Foyth, Davies, Skipp, Lamela, Llorente.
Referee: Michael Oliver.