Ross Barkley, scorer of two goals for England at the start of the week, takes the place of injured N'Golo Kante in midfield.
That's the only change from the side that began the big win over Southampton before the international break.
It means Callum Hudson-Odoi and Willian will again flank Tammy Abraham in attack, with Mason Mount joining Jorginho and Barkley in midfield.
With Andreas Christsensen out with a hamstring problem, Fikayo Tomori and Kurt Zouma continue as the centre-back pairing. Marcos Alonso is left-back with Emerson Palmieri still unavailable.
Unsurprisingly Newcastle are unchanged from their most recent game when they defeated Manchester United.
Chelsea Kepa; Azpilicueta (c), Zouma, Tomori, Alonso; Barkley, Jorginho, Mount; Willian, Abraham, Hudson-Odoi.
Substitutes Caballero, James, Guehi, Kovacic, Pulisic, Batshuayi, Giroud.
Newcastle Dubravka; Yedlin, Schar, Lascelles (c), Clark, Willems; Almiron, M Longstaff, S Longstaff, Saint-Maximin; Joelinton.
Substitutes: Darlow, Dummett, Krafth, Shelvey, Atsu, Carroll, Gayle.
The referee is Andre Marriner.
Chelsea have won our past seven matches at Stamford Bridge against Newcastle in all competitions, scoring 20 while conceding just three goals.
Newcastle have won one of their last 25 away league games against Chelsea (seven draws, 17 defeats), winning 2-0 under Alan Pardew in May 2012.
Against no other side have Chelsea won more Premier League matches at home than we have against Newcastle (17 – as many as against Tottenham).
Chelsea have not kept a clean sheet in any of our past six Premier League meetings with Newcastle.
Chelsea are hoping for a fifth successive win in all competitions for the first time since November 2018.
Tammy Abraham is the first English player to score as many as eight goals in his side’s first eight Premier League games of a season since Wayne Rooney in 2011/12 (nine).
The Blues have netted 18 goals so far in the Premier League this term. Only Liverpool (20) and Man City (27) have scored more.
In his playing career for the Blues, Frank Lampard won 15, drew five and lost six of his games against the Magpies, scoring six goals. He scored seven goals against sides managed by Steve Bruce during his Premier League career.