Olivier Giroud takes the place of injured Tammy Abraham up front.
While that change to the team is enforced, Frank Lampard freshens the side up further after the sapping 90 minutes in Spain three days ago by bringing back Fikayo Tomori and Emerson Palmieri in defence, Mason Mount in midfield and Pedro comes in for Willian in attack.
Jorginho is captain with Cesar Azpilicueta rested on the bench. Andreas Christensen and N'Golo Kante are the other players moved from the team to the subs. Fit-again Callum Hudson-Odoi is also on the bench.
Among the West Ham changes is a debut for 33-year-old David Martin in goal with Roberto dropped. The visitors bring Fabian Balbuena into their central defence for suspended Issa Diop who was previously ever-present.
Chelsea Kepa; James, Zouma, Tomori, Emerson; Kovacic, Jorginho (c), Mount; Pedro, Giroud, Pulisic.
Subs Caballero, Azpilicueta, Christensen, Kante, Willian, Hudson-Odoi, Batshuayi.
West Ham Martin, Fredericks, Balbuena, Ogbonna, Cresswell, Rice, Noble (c), Snodgrass, Fornals, Anderson, Antonio.
Subs Roberto, Zabaleta, Sanchez, Masuaku, Yarmolenko, Haller, Ajeti.
The referee is Jon Moss.
Chelsea are unbeaten in our last 13 home Premier League meetings with West Ham (nine wins, four draws) since a 2-3 loss in September 2002 when Glenn Roeder was in charge of the Hammers.
West Ham have won one of their last seven Premier League meetings with Chelsea (three draws, three defeats), a 1-0 victory at home under David Moyes in December 2017.
Chelsea are playing our 250th London derby in the Premier League.
The Blues have only lost one of our last 15 Premier League games at Stamford Bridge (nine wins, five draws), losing 1-2 to Liverpool in September.
Frank Lampard’s side are seeking a fourth successive home league victory with a clean sheet for the first time since a run of five between November 2014 and January 2015.
The Blues have won our last six Premier League London derbies at Stamford Bridge, keeping clean sheets in the last four that all ended 2-0.
Chelsea have opened the scoring in more Premier League games than any other side this season (11).
West Ham are winless in their last seven Premier League games (two draws, five defeats) since defeating Manchester United in September, losing each of the last three while conceding three goals each time.
West Ham have failed to score in more away games in 2019 than any other Premier League side (eight).