Fikayo Tomori, Marcos Alonso and Mateo Kovacic come into a side that shows three changes to the one that lost to Bournemouth.
There are three centre-back selected with Tomori added to Kurt Zouma and Toni Rudiger.
Emerson Palmieri, Jorginho and Christian Pulisic are the three players replaced with Mason Mount likely to move into a more forward role.
Tottenham are unchanged from their win at Wolves last time out.
Chelsea Kepa; Rudiger, Zouma, Tomori; Azpilicueta (c), Kante, Kovacic, Alonso; Mount, Abraham, Willian.
Subs Caballero, Christensen, James, Jorginho, Pulisic, Hudson-Odoi, Batshuayi.
Tottenham Gazzaniga; Aurier, Sanchez, Alderweireld, Vertonghen; Sissoko, Dier; Moura, Alli, Son; Kane (c).
Subs Vorm, Rose, Foyth, Winks, Lo Celso, Ndombele, Eriksen.
The referee is Anthony Taylor.
Chelsea have won more Premier League matches against Tottenham (28) than we have against any other team in the competition.
Tottenham have won three and lost two of their past five Premier League games against Chelsea.
Chelsea have won two of our past 13 away league games against Tottenham (five draws, six defeats).
We have won 11 away Premier League games against Tottenham – only versus Southampton (13) and Man City (12) have we won more on the road in the competition.
Tottenham are looking to win three consecutive home games against Chelsea in all competitions for the first time in their history.
No team has won more Premier League London derby matches than Chelsea (128, level with Arsenal), while only West Ham (100) have lost more such games than Tottenham (87).
Chelsea have lost four of our past five Premier League matches. We have not lost three consecutive Premier League games since November 2015.
We regret that due to circumstances beyond our control today, there will not be the usual live text commentary in the Match Centre.