Andreas Christensen comes into the side for today's game and are also starts for Marcos Alonso, Ross Barkley and Willian.
The Danish defender makes only his second Premier League start of the campaign and partners David Luiz at the heart of the back four, while Alonso replaces Emerson at left-back.
Further forward, Barkley is given the nod over Mateo Kovacic in midfield and Willian starts on the right of the attacking trio, with Gonzalo Higuain leading the line.
Both Ruben Loftus-Cheek and Callum Hudson-Odoi are among the subs.
Kepa; Azpilicueta (c), Christensen, David Luiz, Alonso; Kante, Jorginho, Barkley; Willian, Higuain, Hazard.
Subs: Caballero, Rudiger, Kovacic, Loftus-Cheek, Pedro, Hudson-Odoi, Giroud.
Lossl, Smith, Kongolo, Bacuna, Billing, Kachunga, Mooy, Diakhaby, Lowe, Mbenza, Schindler.
Subs: Hamer, Grant, Pritchard, Mounie, Zanka, Hadergjonaj, Puncheon.
Today's referee is Paul Tierney.
Maurizio Sarri’s side have won 15 and drawn four of our 20 home games this season. Our only defeat was against Leicester before Christmas.
The Blues have lost just one of our last 15 home games in the Premier League (eight wins, six draws).
Andreas Christensen’s next start will be his 50th for the club in all competitions.