Mateo Kovacic returns to the starting line-up and as Reece James has not recovered from the injury he suffered at Newcastle on Saturday, Emerson Palmieri returns to the side.
Cesar Azpilicueta moves from the left over to right-back with Mason Mount the player making way for Kovacic.
The front three remains the same – Tammy Abraham, who scored the winner at Arsenal last month, flanked by Callum Hudson-Odoi and Willian.
Arsenal make one change from their draw at home to Sheffield United at the weekend. Hector Bellerin comes into their defence and captains the side with Ainsley Maitland-Niles dropped to the bench. Pierre-Emerick Aubameyang is suspended.
Chelsea: Kepa; Azpilicueta (c), Rudiger, Christensen, Emerson; Kante, Jorginho, Kovacic; Hudson-Odoi, Abraham, Willian.
Subs: Caballero, Zouma, Alonso, Barkley, Mount, Pedro, Batshuayi.
Arsenal: Leno; Bellerin, (c), Mustafi, David Luiz, Saka; Torreira, Xhaka; Pepe, Ozil, Martinelli; Lacazette (c).
Subs: Martinez, Maitland-Niles, Holding, Ceballos, Willock, Guendouzi, Nketiah.
.The referee is Stuart Attwell
There will be reaction to the team selection on the new Matchday Live show on The 5th Stand app from 8pm.
Chelsea play Arsenal for the 200th occasion in all competitions, more than we’ve played against any other club.
Arsenal have won two of their last 16 Premier League meetings with Chelsea (five draws, nine defeats), both at the Emirates – 3-0 in September 2016 and 2-0 in January 2019.
Arsenal are winless in their last seven Premier League away games against Chelsea (one draw, six defeats) since winning 5-3 in October 2011.
We are looking to complete the league double over the Gunners for the first time since 2015/16 and fifth in the Premier League era. Only Liverpool (five) and Man Utd (five) have done this against the Gunners on as many as five occasions.
Frank Lampard’s side are seeking consecutive home league wins for the first time since October/November when we beat Brighton, Newcastle and Crystal Palace in succession.
Lampard is looking to become the first English Chelsea manager to do the league double against Arsenal since Dave Sexton in 1969/70.
The Blues have lost once in our last eight home London derbies in the Premier League (six wins, one draw), although it came in the most recent one, vs West Ham in November. We have not lost successive Premier League London derbies at Stamford Bridge since October 1999.