Frank Lampard has named the same side that began the win over Tottenham at the weekend.
That means Olivier Giroud will start for the second game in a row, with Ross Barkley and Mason Mount in support in attack.
Two players who have plenty of experience against Bundesliga opposition, Toni Rudiger and Andreas Christensen, are in central defence and behind them, Willy Caballero plays his first Champions League game for Chelsea although he featured in the competition on many occasions in his Man City and Malaga days.
Bayern Munich make four changes from their weekend win, with former Liverpool man Philippe Coutinho dropped to the bench.
Chelsea Caballero; Azpilicueta (c), Christensen, Rudiger; James, Jorginho, Kovacic, Alonso; Barkley, Mount; Giroud
Subs Kepa, Zouma, Emerson, Gilmour, Willian, Pedro, Abraham
Bayern Neuer (c); Pavard, Boateng, Alaba, Davies; Thiago, Kimmich; Gnabry, Muller, Conman; Lewandowski
Subs Ulreich, Odriozola, Goretzka, Hernandez, Tolisso, Coutinho, Zirkzee
The referee is Clement Turpin
The four previous matches in all competitions between Chelsea and Bayern Munich have produced 17 goals, an average of 4.25 per game.
Bayern and Chelsea first met in the 2004/05 Champions League quarter-finals, Jose Mourinho's Blues prevailing 6- 5 on aggregate against Felix Magath's Bayern. Chelsea won the first leg 4-2 at home, Frank Lampard scoring twice with Didier Drogba also on target. Lampard and Drogba struck again in the second leg as Bayern won 3-2 on the night but went out on aggregate.
Our most recent meeting was in the Super Cup in 2013 when Bayern won on penalties after extra-time with Pep Guardiola in charge.
Of the 22 players who stared the 2012 Champions League final, just three remain – all for Bayern Munich - Manuel Neuer, Jerome Boateng and Thomas Müller.
Frank Lampard scored three goals in four Champions League games against Bayern Munich as a player, his joint-best record in the competition. He also converted one of the penalties in the victorious shoot-out in the 2012 final.
Lampard is the first English manager to progress a team from the Champions League group stage – having taken charge of all six group games – since Harry Redknapp with Tottenham in 2010/11.