Frank Lampard makes two changes to the side that started at Aston Villa, with Ross Barkley and Christian Pulisic both selected.
The American scored off the bench in Birmingham and replaces Ruben Loftus-Cheek in attack, while Barkley comes in for Mateo Kovacic.
Otherwise it is the same starting XI as on Sunday, meaning Andreas Christensen is paired alongside Toni Rudiger in central defence. N’Golo Kante is expected to operate at the base of the midfield three again, with Jorginho, back from suspension, on the bench.
Man City make six changes to their Monday night team against Burnley. They start without a recognised striker, with Gabriel Jesus on the bench and Sergio Aguero injured.
Chelsea Kepa; Azpilicueta (c), Rudiger, Christensen, Alonso; Barkley, Kante, Mount; Willian, Giroud, Pulisic.
Subs Caballero, James, Zouma, Jorginho, Gilmour, Kovacic, Loftus-Cheek, Pedro, Abraham.
Man City Ederson; Walker, Laporte, Fernandinho (c), Mendy; B Silva, Rodrigo, Gundogan; Mahrez, Sterling, De Bruyne.
Subs Carson, Zinchenko, Jesus, Sane, D Silva, Otamendi, Doyle, Harwood-Bellis, Palmer.
Chelsea and Manchester City lock horns for the 150th time in the league. The Blues have won 60 and lost 50 of the previous 149 meetings.
This will be only the second time Chelsea have faced Manchester City on a Thursday, the other being a 2-1 win for the Blues at Stamford Bridge on Boxing Day in 1935.
Man City have won six and lost three of their past nine Premier League meetings with Chelsea.
The Citizens have lost more Premier League games against Chelsea (25) than they have against any other side in the competition.
City won the reverse fixture 2-1 at the Etihad in November. The scorers were N'Golo Kante (21 minutes), Kevin De Bruyne (29), Riyad Mahrez (37).
Chelsea are unbeaten in four Premier League games (winning three), netting at least twice in all four of these matches.
Chelsea are aiming to win three consecutive home Premier League games for the first time since November 2019.
Chelsea had 74 per cent possession in our win at Aston Villa, the 29th time this season we have had the majority of possession in a Premier League game, more than any other side.
Olivier Giroud has scored in three of the Chelsea’s past four Premier League games.