There are two changes to the starting line-up from the win at Crystal Palace midweek.
Jorginho replaces injured Billy Gilmour in the heart of midfield, having come on late in the game at Selhurst Park, and Tammy Abraham leads the attack having made a scoring impact as a substitute in Tuesday's game.
Seventeen-year-old Academy midfielder Lewis Bate is among the subs for the first time.
Sheffield United make one change with fit-again David McGoldrick replacing Billy Sharp up front.
Chelsea: Kepa; James, Zouma, Christensen, Azpilicueta (c); Barkley, Jorginho, Mount; Willian, Abraham, Pulisic.
Subs: Caballero, Rudiger, Alonso, Bate, Kovacic, Loftus-Cheek, Hudson-Odoi, Batshuayi, Giroud.
Sheffield United: Henderson; Basham, Egan, O’Connell; Baldock, Berge, Norwood (c), Osborn, Stevens; McBurnie, McGoldrick.
Subs: Moore, Jagielka, Freeman, Robinson, Lundstram, Rodwell, Mousset, Zivkovic, Sharp.
Referee: Andre Marriner
The Blues and the Blades meet for the fourth time at Bramall Lane in the Premier League and first since 2006/07.
Dave Bassett was in charge the last occasion Sheffield Utd beat the Blues, in November 1993. Willie Falconer scored the only goal at Bramall Lane in the first half.
The reverse fixture this season at Stamford Bridge in August ended 2-2 after the Blues let a two-goal lead slip. It was the first point Sheffield United had taken from the Bridge since 1992/93. Tammy Abraham with two, Callum Robinson and a Kurt Zouma own-goal were on the scoresheet.
Frank Lampard’s side have won five of our last six Premier League games.
Chelsea have scored two or more goals in 10 of our last 11 Premier League games, only failing to do so in the 0-2 loss to Man Utd at Stamford Bridge in February.
Lampard’s side have the second-best away record in the Premier League with 30 points from 17 matches. Only Liverpool have gained more (41).
No side has scored more Premier League goals on the road this term than Chelsea (36).