Christian Pulisic starts his first Premier League game since October in the only change to the Chelsea starting line-up from the weekend defeat at Everton.
The American replaces Mateo Kovacic in the side and is expected to play one of the wide attacking roles in our 4-3-3 system, with Timo Werner on the opposite flank. Olivier Giroud retains his place as the spearhead of the attack.
Kai Havertz is likely to revert to a more central position alongside Mason Mount, who scored on this ground last season, and N’Golo Kante. The settled back five remain unchanged, with Edouard Mendy in goal behind Reece James, Kurt Zouma, Thiago Silva and Ben Chilwell.
Wolves make two changes from Saturday's 1-0 defeat to Aston Villa, with the suspended Joao Moutinho replaced by Ruben Neves, while Willy Boly comes in for Adama Traore as Nuno Espirito Santo's side appear to switch back to a 3-4-2-1 system.
Chelsea (4-3-3) Mendy; James, Zouma, Thiago Silva (c), Chilwell; Kante, Mount, Havertz; Pulisic, Giroud, Werner
Subs Kepa, Azpilicueta, Rudiger, Jorginho, Gilmour, Kovacic, Abraham
Wolves Rui Patricio; Boly, Coady (c), Saiss; Semedo, Dendoncker, Neves, Marcal; Podence, Silva, Neto
Subs Ruddy, Hoever, Kilman, Ait-Nouri, Vitinha, Otasowie, Traore
The referee is Stuart Attwell
Chelsea lock horns with Wolves for the seventh occasion in the Premier League era. The Blues have won four of the six so far with Wolves winning the other two.
We have not drawn at Molineux in the league since a 1-1 draw in May 1977 in a game that secured our promotion to Division One. Tommy Langley and John Richards scored the goals.
Chelsea achieved the double over Wolves last term having not managed to win either league game the season before.
The Blues have only failed to score in one of our last 17 top-flight meetings with Wolves - a 0-1 defeat at Molineux in January 2011.
The last seven Premier League goals to be scored at Molineux by Chelsea players have been by Englishmen (Frank Lampard, Ruben Loftus-Cheek, Fikayo Tomori, Tammy Abraham (three) and Mason Mount).
Our defeat at Everton ended our 17-game unbeaten run in all competitions since our defeat to Liverpool on 20 September.
Chelsea conceded our first penalty of the season at Goodison Park and the first since our away Champions League game at Bayern Munich in August.
The last penalty we conceded in the Premier League was over a year ago in November 2019 in our 2-1 win at Watford.
Chelsea are looking to avoid back-to-back Premier League defeats for the first time in a year.
Frank Lampard’s side have yet to lose in a game in which they have led this season.