There are three changes to the side that began the draw against Manchester United last time out.
Timo Werner will lead the attack in place of Olivier Giroud and Jorginho comes in for Mateo Kovacic alongside N'Golo Kante.
Reece James is preferred to Callum Hudson-Odoi at right wing-back.
By making his 411th appearance for the club tonight, Cesar Azpilicueta becomes our 10th all-time highest appearance maker.
Ahead of kick-off, Thomas Tuchel explained his selection.
‘We need speed against a high line and Timo has the speed so this is why he’s in,' he said.
‘When the game becomes maybe more deeper and we have more crosses or set-pieces then it’s more for Oli [Giroud] but to start with it’s Timo.
‘Reecey in exchange for Callum is for the defensive power and physicality. On the other side, Chilly in for Marcos again is for his speed. Marcos [Alonso] has played very well. He’s a bit taller, stronger on set-pieces and very reliable but Chilly is a bit faster and this is what we expect today because Liverpool attack very fast down the sides with Robertson and Alexander-Arnold. We need to be ready for that.’
For Liverpool, Alisson returns in goal and fit-again Fabinho comes into their central defence.
Chelsea Mendy; Azpilicueta (c), Christensen, Rudiger; James, Kante, Jorginho, Chilwell; Ziyech, Mount; Werner.
Subs Kepa, Zouma, Alonso, Emerson, Kovacic, Havertz, Hudson-Odoi, Pulisic, Giroud.
Liverpool Alisson; Alexander-Arnold, Fabinho, Kabak, Robertson; Thiago, Wijnaldum (c), Jones; Salah, Firmino, Mane.
Subs Adrian, R Williams, N Williams, Milner, Keita, Oxlade-Chamberlain, Jota, Shaqiri, Origi.
The referee is Martin Atkinson.
Chelsea have won one of our past 12 Premier League meetings with Liverpool (five draws, six defeats), beating them 1-0 at the Bridge in May 2018 thanks to a first-half Olivier Giroud strike.
Liverpool are seeking a fifth consecutive Premier League win against Chelsea.
Jose Mourinho was in charge the last time we came away from Anfield with three points. Cesar Azpilicueta was in a side that won 2-1 in November 2014 with goals from Gary Cahill and Diego Costa, after Emre Can opened the scoring early on. Since then we have drawn three, all 1-1, and lost the last two.
This will be our 90th game at Anfield and will equal, with Goodison Park, the most games played at an away ground in our history.
Chelsea are hoping to extend our unbeaten run in all competitions to 11 games since our defeat at Leicester on 19 January.
In all competitions, the Blues have won four of our five away games under Thomas Tuchel, drawing the other.
Only Manchester City have conceded fewer Premier League goals this season than Chelsea.
Twenty-nine per cent of our Premier League goals this season have been scored in the last 15 minutes (12/41).