There are five changes for the Blues, including the return of Andreas Christensen, Kai Havertz and Mason Mount…
Thomas Tuchel has opted for Christensen instead of Thiago Silva, while Toni Rudiger also returns at the back in place of Kurt Zouma.
Cesar Azpilicueta captains the Blues for the 150th time alongside them in our three-man defence, with Reece James and Ben Chilwell at wing-back and Edouard Mendy in goal. James makes his 50th Chelsea start.
Jorginho partners Mateo Kovacic in central midfield once again, with Mount back in along with Kai Havertz in support of Timo Werner up top.
Porto are without midfielder Sergio Oliveira, their top scorer, and striker Mehdi Taremi through suspension. On-loan defender Malang Sarr is eligible to feature and starts among the substitutes, as does N'Golo Kante.
Chelsea (3-4-3) Mendy; Azpilicueta (c), Christensen, Rudiger; James, Jorginho, Kovacic, Chilwell; Havertz, Mount, Werner
Subs Kepa, Caballero, Alonso, Emerson, Thiago Silva, Zouma, Kante, Hudson-Odoi, Ziyech, Pulisic, Abraham, Giroud
Porto (4-4-2) Marchesin; Manafa, Mbemba, Pepe, Sanusi; Corona, Grujic, Uribe, Otavio; Luis Diaz, Marega
Subs Ramos, Sarr, Vieira, Anderson, Baro, Evanilson, Conceicao, Joao Mario, Leite, Martinez, Nanu, Ndiaye
The referee is Slavko Vincic from Slovenia.
Chelsea and Porto are drawn together for the fifth time, all in the Champions League. Three of the four previous occasions were in the group stage.
The other was in the 2006/07 round of 16 when Chelsea progressed 3-2 on aggregate.
Our only other competitive game at Seville’s Estadio Ramon Sanchez-Pizjuan was in the group stage in December when we defeated Sevilla 4-0.
We played PSG on the last occasion, in 2013/14 when Jose Mourinho was in charge, and we progressed to the semi-finals on away goals having drawn the tie 3-3 on aggregate.
This is our 10th quarter-final in the competition. We have progressed in seven of the previous nine.
Chelsea have reached the Champions League quarter-final without losing a game for only the second time. 2007/08 was the other when we went on to lose the final in Moscow.
The loss at Bayern Munich last season is our only defeat in 15 European away matches (11 wins, three draws).
Our record against Portuguese clubs is 10 wins, one draw and two defeats. Away from home we have won three, drawn one and lost two (both to Porto).
Chelsea have won all three knockout games against Portuguese sides; Porto in 2006/07 and Benfica 2011/12 (both in the Champions League quarter-finals) and the Europa League final against Benfica in 2013.