Thomas Tuchel makes one change to the Chelsea side that started in Spain last week, with Kai Havertz replacing Christian Pulisic in attack.
That means Toni Rudiger is passed fit to play after picking up a knock late on in the first leg. He is expected to wear a mask.
In all there are four changes to the team that began the weekend win over Fulham, with Rudiger, Jorginho, N’Golo Kante and captain Cesar Azpilicueta returning.
Kante makes his 50th appearance of the season for club and country.
Eden Hazard starts for Real Madrid, as do Sergio Ramos and Ferland Mendy. They are expected to switch to a 4-3-3 shape, with Vinicius Junior supplementing Hazard and Karim Benzema in attack.
Chelsea (3-4-3): Mendy; Christensen, Thiago Silva, Rudiger; Azpilicueta (c), Kante, Jorginho, Chilwell; Mount, Havertz, Werner.
Subs: Caballero, Kepa, Alonso, Emerson, James, Zouma, Gilmour, Hudson-Odoi, Pulisic, Ziyech, Abraham, Giroud.
Real Madrid (4-3-3): Courtois; Nacho, Militao, Ramos (c), Mendy: Modric, Casemiro, Kroos; Vinicius, Benzema, Hazard.
Subs: Altube, Lunin, Odriozola, Marcelo, Miguel Gutierrez, Blanco, Valverde, Isco, Arribas, Asensio, Rodrygo, Mariano.
The referee is Daniele Orsato from Italy.