Thomas Tuchel makes three changes from the side that began against Zenit in the Champions League midweek.
'Edou got a huge hit, we tried everything in the last days but he never felt fully comfortable in diving.' reported Tuchel before kick-off.
Thiago Silva comes into defence so Cesar Azpilicueta is expected to move to right wing-back with Reece James dropping to the bench.
Kai Havertz replaces Hakim Ziyech. The German joins Mason Mount in supporting Romelu Lukaku who continues to lead the attack.
N’Golo Kante is back among the subs after injury.
For Tottenham, Son Heung-Min has been passed fit and starts. Recent signing Cristian Romero comes into their defence for suspended Japhet Tanganga.
Chelsea Kepa; Christensen, Thiago Silva, Rudiger; Azpilicueta (c), Jorginho, Kovacic, Alonso; Mount, Lukaku, Havertz.
Substitutes: Bettinelli, Chilwell, James, Chalobah, Kante, Saul, Hudson-Odoi, Ziyech, Werner.
Tottenham Lloris (c); Royal, Romero, Dier, Reguilon; Ndombele, Hojbjerg, Alli; Lo Celso, Son, Kane.
Substitutes Gollini, Doherty, Rodon, Sanchez, Davies, Winks, Skipp, Bryan, Scarlett
The referee is Paul Tierney.