Thomas Tuchel makes eight changes to his Chelsea team with fresh faces in goal, defence, midfield and attack.
Kepa replaces Edouard Mendy between the posts, and there are starts for Cesar Azpilicueta and Malang Sarr in the back three. Callum Hudson-Odoi is at right wing-back, with Saul Niguez on the opposite flank and Ross Barkley occupying a midfield role.
Zenit make a couple of changes from their matchday five line-up, with the suspended Dmitri Chistyakov replaced by Daler Kuzyaev.
Chelsea: Kepa, Azpilicueta (c), Christensen, Sarr, James, Mount, Barkley, Saul, Hudson-Odoi, Werner, Lukaku
Subs: Bettinelli, Mendy, Alonso, Rudiger, Thiago Silva, Loftus-Cheek, Havertz, Pulisic, Ziyech
Zenit: Kerzhakov; Barrios, Lovren (c), Rakitskiy; Karavaev, Kuzyaev, Wendel, Santos; Malcom, Claudinho; Azmoun
Subs: Odoevski, Byazrov, Krugovoi, Mostovoy, Sutormin, Erokhin, Dzyuba, Ozdoev, Kravtsov, Kuznetsov, Khotulev
The referee is Serdar Gozubuyuk from the Netherlands
- Keep predicting with The 12 Games of Christmas this festive season! WIN Kai Havertz and Lauren James' signed shirts by playing Wednesday's games. Play all 12 up to 26 December 26 and to be in the draw to WIN a TV and Sonos soundbar!
- The games for Zenit and Juventus Women are now open on The 5th Stand