Christian Pulisic was injured in the warm-up at Burnley so is replaced by Timo Werner.
The American was originally one of six changes from the Champions League game in Krasnodar but that is now down to five.
Thiago Silva returns and also back in the defence is Reece James. There are places for N'Golo Kante, Mason Mount and Tammy Abraham.
Cesar Azpilicueta, Toni Rudiger, Jorginho, Mateo Kovacic and Callum Hudson-Odoi are the players making way.
Explaining his team selection, Frank Lampard said: 'The changes you see are for freshness and me having faith in the squad.
'There are fresh legs in there from the team the other day so we just have to come here and try to be at our best. We’ve had clean sheets and scored goals in midweek so we just need to keep building on that.’
Burnley make one change from their defeat at home to Tottenham on Monday. With winger Johann Berg Gudmundsson out injured, Dale Stephens comes in.
Chelsea Mendy; James, Thiago Silva (c), Zouma, Chilwell, Mount, Kante, Havertz, Ziyech, Abraham, Werner.
Subs Caballero, Ziger, Azpilicueta, Rudiger, Jorginho, Hudson-Odoi, Giroud.
Burnley Pope; Lowton, Long, Tarkowski, Taylor, Stephens, Westwood (c), Brownhill, McNeil, Barnes, Wood.
Subs Peacock-Farrell, Dunne, Brady, Thompson, Richardson, Rodriguez, Vydra.
The referee is David Coote.
Stats recap
Chelsea have lost just one of our 12 Premier League games against Burnley (eight wins, three draws), a 3-2 defeat at Stamford Bridge on the opening day of 2017/18.The Blues have won five of our six Premier League away games against Burnley, scoring at least twice in each victory.We are unbeaten at Turf Moor since losing 0-3 in April 1983 in the old Second Division.The Blues last lost a top-flight encounter at Turf Moor in August 1973, when we were beaten by an 80th-minute Frank Casper goal with Dave Sexton in charge.
Hakim Ziyech and Christian Pulisic both scored their first goals of the season on Wednesday against Krasnodar, taking our total to 13 different scorers in just 10 games in 2020/21.Chelsea have scored 45 away goals in the Premier League since the start of last season. Only Man City (50) have netted more in the same period.The Blues are hoping to keep consecutive away clean sheets in the Premier League for the first time since October 2018.Edouard Mendy is looking to become the first keeper to keep a clean sheet in his first three Premier League appearances for the Blues since Petr Cech in August 2004.