Chelsea forward Cole Palmer has been named in Thomas Tuchel's England squad for the clashes with Uruguay and Japan, while a pair of young Blues have been selected by the Under-21s.
Palmer had missed England's previous three camps this season due to injury but with the 23-year-old back playing regularly for Chelsea, he has been recalled by former Blues boss Tuchel.
As expected, Trevoh Chalobah, Levi Colwill and Reece James all miss out this time around due to their respective injuries.
England will play two games at Wembley Stadium during the next camp. First the Three Lions will face Uruguay on Friday 27 March before taking on Japan on Tuesday 31 March, with both matches kicking off at 7.45pm.
Palmer will hope to add to his 12 senior England caps and two goals as he looks to secure a place on the plane to this summer's World Cup in Canada, Mexico and the USA.
Meanwhile at Under-21 level, Josh Acheampong and Tyrique George - who is currently on loan at Everton - are in Lee Carsley's squad for a pair of European Championship qualifiers.
The Young Lions play Andorra on Friday 27 March at the Estadi National in Andorra la Vella, before returning to home soil to take on Moldova at Norwich's Carrow Road on Tuesday 31 March. They are looking to build on their perfect start to qualifying for next summer's showpiece in Albania and Serbia.
We will bring you news of the other Chelsea call-ups over the coming days.
England squad for Uruguay and Japan
Goalkeepers: Dean Henderson (Crystal Palace), Jordan Pickford (Everton), James Trafford (Manchester City), Aaron Ramsdale (Newcastle United), Jason Steele (Brighton & Hove Albion)
Defenders: Dan Burn (Newcastle United), Marc Guéhi (Crystal Palace), Lewis Hall (Newcastle United), Ezri Konsa (Aston Villa), Tino Livramento (Newcastle United), Harry Maguire (Manchester United), Nico O'Reilly (Manchester City), Jarell Quansah (Bayer Leverkusen), Djed Spence (Tottenham Hotspur), John Stones (Manchester City), Fikayo Tomori (AC Milan)
Midfielders: Elliot Anderson (Nottingham Forest), Jude Bellingham (Real Madrid), James Garner (Everton), Jordan Henderson (Brentford), Kobbie Mainoo (Manchester United), Declan Rice (Arsenal), Morgan Rogers (Aston Villa), Adam Wharton (Crystal Palace)
Forwards: Jarrod Bowen (West Ham United), Dominic Calvert-Lewin (Leeds United), Eberechi Eze (Arsenal), Phil Foden (Manchester City), Anthony Gordon (Newcastle United), Harry Kane (Bayern Munich), Noni Madueke (Arsenal), Cole Palmer (Chelsea), Marcus Rashford (Barcelona, loan from Manchester United), Bukayo Saka (Arsenal), Dominic Solanke (Tottenham Hotspur)
England Under-21 squad for Andorra and Moldova
Goalkeepers: James Beadle (Birmingham City, loan from Brighton and Hove Albion), Tommy Setford (Arsenal), Tommy Simkin (Stoke City)
Defenders: Josh Acheampong (Chelsea), Max Alleyne (Manchester City), Rico Lewis (Manchester City), Myles Lewis-Skelly (Arsenal), Ben Nelson (Leicester City), Brooke Norton-Cuffy (Genoa), Ashley Phillips (Stoke City, loan from Tottenham Hotspur), Thierry Small (Preston North End)
Midfielders: Jobe Bellingham (Borussia Dortmund), Kellen Fisher (Norwich City), Archie Gray (Tottenham Hotspur), Jack Hinshelwood (Brighton and Hove Albion), Sydie Peck (Sheffield United)
Forwards: Samuel Amo-Ameyaw (Strasbourg), Tyler Dibling (Everton), Romain Esse (Coventry City, loan from Crystal Palace), Tyrique George (Everton, loan from Chelsea), Josh King (Fulham), Divin Mubama (Stoke City, loan from Manchester City), Ethan Nwaneri (Marseille, loan from Arsenal)