Enzo Maresca names the same Chelsea XI for the third Premier League game in a row, meaning there are 10 changes to the side that started against Djurgarden on Thursday.
Marc Cucurella is the only player to retain his place and he is joined in defence by Levi Colwill, Trevoh Chalobah and Moises Caicedo.
Romeo Lavia and Enzo Fernandez continue in midfield, with Pedro Neto, Cole Palmer and Noni Madueke supporting Nicolas Jackson.
The bench includes Reece James, Jadon Sancho and Tyrique George.
Newcastle make two changes to the team that started at Brighton, with Kieran Trippier and Joe Willock not involved. Sven Botman and Anthony Gordon come into the starting XI.
Chelsea: Sanchez; Caicedo, Chalobah, Colwill, Cucurella; Lavia, Fernandez (c); Neto, Palmer, Madueke; Jackson
Substitutes: Jorgensen, Gusto, James, Acheampong, Badiashile, Tosin, Dewsbury-Hall, George, Sancho
Newcastle: Pope, Botman, Schar, Burn, Livramento, Guimaraes (c), Tonali, Barnes, Murphy, Isak, Gordon
Substitutes: Dubravka, Ruddy, Lascelles, Krafth, Longstaff, Miley, Neave, Osula, Wilson
The referee is John Brooks