Tosin Adarabioyo and Jadon Sancho have come into the starting XI in place of Trevoh Chalobah, who was injured at Aston Villa on Saturday, and Reece James.

That means Filip Jorgensen starts in goal, behind a back four of Malo Gusto, Tosin, Levi Colwill and Marc Cucurella.

Moises Caicedo and Enzo Fernandez begin in midfield, with Cole Palmer, Christopher Nkunku, Jadon Sancho and Pedro Neto in the attacking positions.

There is also a return to the matchday squad for Wesley Fofana following his return from injury. His last appearance in Blue came on December 1.

Chelsea: Jorgensen, Gusto, Tosin, Colwill, Cucurella, Caicedo, Enzo (c), Sancho, Palmer, Nkunku, Neto

Substitutes: Sanchez, James, Acheampong, Fofana, Samuels-Smith, Amougou, Dewsbury-Hall, George, Mheuka

Southampton: Ramsdale; Sugawara, Bree, Bella-Kotchap, Walker-Peters; Downes, Smallbone, Fernandes; Aribo, Kamaldeen, Onuachu

Substitutes: McCarthy, Stephens, Harwood-Bellis, Wood, Manning, Wellington, Grønnbæk, Dibling, Archer