For her final London derby, Emma Hayes makes three changes from the side that thumped Bristol City last time out.
Catarina Macario returns up front while Aggie Beever-Jones, fresh from her England call-up and two goals against Bristol City, retains her place in attack.
Guro Reiten, the scorer of four goals in that last game, also starts again, as does Maika Hamano, but there is a change in midfield with Melanie Leupolz in for Sophie Ingle. In defence, Ashley Lawrence replaces Eve Perisset who is not involved tonight.
Top scorer Lauren James returns from a foot injury to take a place on the bench but Jelena Cankovic and Mayra Ramirez remain out.
The Tottenham side also shows three changes from their FA Cup final defeat against Manchester United. Former Chelsea players Drew Spence and Bethany England both start.
Chelsea Musovic; Lawrence, Bright (c), Bjorn, Charles, Cuthbert, Leupolz, Reiten, Hamano, Beever-Jones, Macario
Subs Hampton, Buchanan, Carter, Mjelde, Ingle, Nusken, Kirby, Rytting Kaneryd, James
Tottenham Votikova, Neville, James-Turner, Buhler, Nilden, Spence, Summanen, Clinton, Bizet, England (c), Naz
Subs Heeps, Grant, Ahtinen, Petzelberger, Wang, Ayane, Thomas, Vinberg, Graham
Referee Emily Heaslip