Three changes have been made to the side which started the draw against West Ham at the weekend.
Borussia Dortmund vs Chelsea line-ups
In central defence, Kalidou Koulibaly replaces Benoit Badiashile who is not in the Champions League squad.
Ben Chilwell on the left makes his first start since early November. Hakim Ziyech also returns to the starting line-up in place of Noni Madueke, another new signing not added to the squad for European games.
Kai Havertz, back in his homeland, will again lead the attack.
For Borussia Dortmund, former West Ham forward Sebastien Heller replaces the injured Youssoufa Moukoko. Jude Bellingham is named captain.
Chelsea: Kepa; James, Thiago Silva (c), Koulibaly, Chilwell, Loftus-Cheek, Joao Felix, Enzo, Ziyech, Havertz, Mudryk.
Subs: Bettinelli, Bergstrom, Azpilicueta, Cucurella, Hall, Chalobah, W Fofana, Chukwuemeka, Gallagher, Kovacic, Mount, Zakaria.
Dortmund: Kobel; Wolf, Sule, Schlotterbeck, Guerreiro, Can, Adeyemi, Bellingham (c), Ozcan, Brandt, Haller.
Subs: Meyer, Hummels, Ryerson, Meunier, Reyna, Reus, Dahoud, Malen, Rothe, Bynoe-Gittens, Coulibaly, Modeste.
The referee is Jesus Gil Manzano from Spain.