Pedro Neto, Estevao Willian and a selection of young Blues were all involved in another action-packed day of international action.
Neto started for Portugal in their 4-1 defeat to Denmark in the UEFA Nations League, with fellow Blue Geovany Quenda an unused substitute for the hosts. Chelsea goalkeeper Filip Jorgensen was also named among the substitutes for Denmark.
Our winger was replaced with just under half an hour remaining, as Portugal suffered their first defeat of the campaign. Despite the result, they remain top of League A Group 4, three points ahead of the Danes.
Elsewhere in the Nations League, Genesis Antwi was an unused substitute as Sweden secured a 3-2 victory over Bosnia and Herzegovina. The Swedes are now five points clear at the top of League B Group 4.
Meanwhile, Estevao started for Brazil in their 3-2 defeat to Japan in Singapore. Japan raced into a 2-0 lead through Takefusa Kubo and Keito Nakamura before Vinicius Junior pulled one back for Brazil. Estevao came close to finding the net, but was denied by Japan goalkeeper Zion Suzuki.
The Blues winger was replaced by Alisson Santana shortly before the hour mark, and Vinicius struck again in the 75th minute to bring Brazil level.
However, Japan had the final say as Tatsuhiro Sakamoto scored a dramatic stoppage-time winner, securing his country's second victory over Brazil.
At youth level, England's Under-18s suffered a 3-0 defeat to Sweden in their second fixture of the November international window.
Five Chelsea representatives featured in the contest, with Calvin Diakite, Ryan Kavuma-McQueen and Riley Ebho all starting, while Jashayde Greenwood and Gabriel Sambou were introduced from the bench.
There was better news for England's Under-19s, who made it two wins from two with an emphatic 5-0 victory over Belarus in UEFA European Under-19 Championship qualifying.
Chelsea forward Chizaram Ezenwata was among the goalscorers, converting a penalty to score the Young Lions' fourth of the afternoon.
Fellow Blues Freddy Bernal, Landon Emenalo and Reggie Walsh were also involved, with all three starting the contest.
England's Under-17s also continued their impressive qualifying campaign with a 2-0 victory over Poland.
Chelsea trio Reggie Watson, Josh Henry and Mahdi Nicoll-Jazuli were all named in the starting line-up as the Young Lions secured their second consecutive win in UEFA European Under-17 Championship qualifying.