Frank Lampard makes three changes to the starting side.
Opportunities in attack are handed to Noni Madueke and Mykhailo Mudryk, and there is a place for Carney Chukwuemeka in midfield.
Thiago Silva, Ruben Loftus-Cheek and Raheem Sterling are the players making way. Sterling has a minor hamstring issue.
Eighteen-year-old Lewis Hall starts for the third game in a row.
Joao Felix returns to the bench having missed our game at Manchester City with a minor problem.
Nineteen-year-old central defender Alfie Gilchrist, who has captained the Chelsea Under-23s side in the second half of the season since Bashir Humphreys went on loan, is named among the subs.
Manchester United are unchanged. Marcus Rashford returns to their bench after injury and illness.
Chelsea: Kepa; Azpilicueta (c), W.Fofana, Chalobah, Hall, Chukwuemeka, Enzo, Gallagher, Madueke, Havertz, Mudryk.
Subs: Mendy, Gilchrist, Koulibaly, Thiago Silva, Loftus-Cheek, Pulisic, Ziyech, D.Fofana, Joao Felix.
Man United: De Gea; Wan-Bissaka, Varane, Lindelof, Shaw, Casemiro, Eriksen, Antony, Fernandes (c), Sancho, Martial.
Subs: Butland, Dalot, Maguire, Malacia, Fred, McTominay, Weghorst, Garnacho, Rashford.
The referee is Stuart Attwell.