Frank Lampard makes three changes to the side that started at Old Trafford on Sunday, including bringing Christian Pulisic into the team for his full Chelsea debut and a return for N’Golo Kante.
Mason Mount and Ross Barkley make way for that duo, while upfront Olivier Giroud leads the attack in place of Tammy Abraham.
With Kante, Mateo Kovacic and Jorginho all starting there is the possibility of a shift to a 4-3-3 shape from the 4-2-3-1 set-up we saw at Old Trafford. Kante played the closing stages in Manchester and has now been deemed fit enough to feature from the off.
Willian and Toni Rudiger are on the bench.
Liverpool start with Alex Oxlade-Chamberlain in the front three and James Milner in midfield.
Chelsea are expected to line up in the following 4-3-3 formation:
Kepa; Azpilicueta (c), Zouma, Christensen, Emerson; Jorginho, Kante, Kovacic; Pedro, Giroud, Pulisic.
Subs: Caballero, Rudiger, Tomori, Alonso, Zappacosta, Gilmour, Barkley, Mount, Kenedy, Willian, Batshuayi, Abraham.
Liverpool line up as follows:
Adrian, Gomez, Matip, Van Dijk, Robertson, Milner, Fabinho, Henderson (c), Oxlade-Chamberlain, Salah, Mane.
Liverpool subs: Lonergan, Kelleher, Hoever, Alexander-Arnold, Elliott, Wijnaldum, Shaqiri, Firmino, Lallana, Brewster, Origi.
Chelsea's recent record in Europe
The Blues reached the Super Cup by beating Arsenal 4-1 in the Europa League final in Baku in May.
Chelsea remained unbeaten in Europe last season (12 wins, three draws), which is also a Europa League record.
Frank Lampard’s side are looking to extend our club record 15-game unbeaten run in Europe. Our last defeat was in March 2018, at Barcelona in the Champions League round of 16 (0-3).
We have scored three or more goals in five of our last eight European matches. Our total of 36 goals last term was one short of the Europa League record, set by Porto in 2010/11.
Chelsea's history in the UEFA Super Cup
Chelsea are competing in our fourth UEFA Super Cup:1998 beat Real Madrid 1-02012 lost 1-4 to Atletico Madrid2013 lost on penalties to Bayern Munich after a 2-2 draw after extra time
Frank Lampard was captain in our 2012 and 2013 defeats.
Chelsea's European record against English teams and in Istanbul
Chelsea have won seven of our 18 meetings against English opposition in Europe, drawing seven and losing four.
Chelsea have played three competitive games in Istanbul (one win, one draw and one defeat) but will be making our first appearance at Besiktas Park. Our 2-0 away win against Besiktas in 2003/04 in the Champions League was played in Gelsenkirchen for security reasons.
Chelsea v Liverpool head-to-head record
Since the start of the 2000s, Wednesday evening’s game will be the 60th meeting between Chelsea and Liverpool in all competitions, making it the most played fixture between English sides in all competitions in the 21st century.
Chelsea and Liverpool have met on 10 previous occasions in European competition, all in the Champions League. 2004/05 semi-final – Liverpool won 1-0 on aggregate2005/06 group stage – both games ended goalless2006/07 semi-final – Liverpool won on penalties after a 1-1 draw on aggregate2007/08 semi-final – Chelsea won 4-3 on aggregate2008/09 quarter-final – Chelsea won 7-5 on aggregate
Super Cup referee
Female French referee Stephanie Frappart will referee the game. She will be joined by assistants Manuela Nicolosi and Michelle O'Neill, with Turkey's Cuneyt Cakir the fourth official. This will be the first time that a female official takes charge of a major UEFA men's competition event.