As in the previous round against Grimsby, Frank Lampard hands starts to young defenders Reece James and Marc Guehi and to midfielder Billy Gilmour.
There are two changes to the 11 which began that 7-1 win and those are in midfield where Jorginho, tonight's captain, and Mateo Kovacic are in place of Ross Barkley and Pedro.
Michy Batshuayi, scorer of the winning goal a week ago at Ajax, leads the attack and there is another start for weekend hat-trick hero Christian Pulisic.
Nineteen-year-old right-back Tariq Lamptey is on the bench for the first time.
Manchester United make four changes from their win at Norwich at the weekend, with Sergio Romero, Marcos Rojo, Jesse Lingard and Brandon Williams coming in.
Chelsea Caballero; James, Guehi, Zouma, Alonso, Gilmour, Jorginho (c), Kovacic, Hudson-Odoi, Batshuayi, Pulisic.
Substitutes Cumming, Azpilicueta, Lamptey, Mount, Pedro, Abraham, Giroud.
Man United Romero, Lindelof, Maguire (c), Rojo, Wan-Bissaka, McTominay, Fred, Lingard, Williams, James, Rashford.
Substitutes Grant, Young, Jones, Pereira, Garner, Mata, Martial.
The referee is Paul Tierney.
Stats recap
Our overall cup record against Man United is seven wins, four draws and 13 defeats.
Man United’s biggest league win at Stamford Bridge is 4-0 in 1947/48 (Division One).Chelsea are hoping for an eighth successive win in all competitions for the first time since our club record run of 10 between October 2016 and Jan 2017.The Blues are looking to progress to the League Cup quarter-final round for the third successive season.The last team to defeat us in the fourth round was West Ham in October 2016 when they beat us 2-1 at the London Stadium with Antonio Conte in charge.
Manchester United have won the League Cup four times in the past 14 seasons.Man United’s Europa League victory in Belgrade last week against Partizan was their first win on the road in all competitions since beating PSG in the Champions League in Paris last March. That run included seven defeats and four draws.They won their first away game in the Premier League since February at Norwich on Sunday.Man United have been awarded six penalties this season and missed four of them, including two at Carrow Road.