Michy Batshuayi starts up front for the Blues in place of the injured Tammy Abraham, while Willy Caballero retains his place in goal for the visit of Manchester United.
There are three changes in total from our last outing, a 2-2 draw at Leicester before the inaugural Premier League winter break, with Mateo Kovacic and Willian returning to the side in place of Mason Mount and Callum Hudson-Odoi.
Toni Rudiger, who bagged a brace last time out, and Andreas Christensen form the central defensive partnership in front of Caballero, with Pedro joining Willian and Batshuayi in attack.
‘They’re both injured,’ Lampard said of Hudson-Odoi and Abraham's absence.
‘Tammy is the same injury that has frustratingly come from Arsenal, played against Leicester, and now out. We will see how that develops for the games ahead.
‘Callum pulled up with a hamstring a couple of days ago in training which we have been assessing. He’s out as well, hopefully not for too long.’
On his goalkeeping decision, the boss added: ‘It’s not an easy decision. With every player in the squad I have to go on form, from what I see on the training ground, off the pitch and what I see in performance.
‘It doesn’t mean anything long term. We have to be competitive here and people have to show. Willy has been a fantastic pro, trains really well, came in against Leicester and made a couple of really good saves in the game.'
United also make three changes from their previous encounter against Wolves, with Brandon Williams, Eric Bailly and former Blue Nemanja Matic coming into the team for Ole Gunnar Solskjaer’s men. New signing Odion Ighalo is on the bench.
Both teams will wear black armbands as a mark of respect to Harry Gregg OBE, the former United goalkeeper who passed away earlier today.
Chelsea: Caballero; James, Rudiger, Christensen, Azpilicueta (c); Jorginho, Kante, Kovacic; Willian, Batshuayi, Pedro
Subs: Kepa, Zouma, Tomori, Alonso, Barkley, Mount, Giroud
Man United: De Gea; Wan-Bissaka, Bailly, Maguire, Williams; Matic, Fred; James, Fernandes, Shaw; Martial
Subs: Romero, Jones, Dalot, Pereira, Mata, Greenwood, Ighalo
The referee is Anthony Taylor.
There will be reaction to the team selection on the Matchday Live show on the 5th Stand app from 7.45pm.
Chelsea have won seven of our past nine away games at Leicester in all competitions, drawing last season and losing 1-2 in the Foxes’ title-winning campaign of 2015/16.
Leicester City are unbeaten in their last four Premier League games against Chelsea (one win, three draws), their best run since a run of five without defeat between April 1999 and February 2001.
Chelsea have failed to score in three of our last four Premier League games against the Foxes.
Manchester United have already won 2-1 at Stamford Bridge in the Carabao Cup this season – the last team to win away at Chelsea twice in the same season were Liverpool in 2011/12.
United are seeking to secure a third successive win at the Bridge in all competitions for the first time since 1985.