Olivier Giroud leads the line up front for Chelsea, while Marcos Alonso makes his first Premier League appearance since the reverse fixture with Tottenham back in December as the Blues switch to three at the back.
There are four changes in total as Alonso is expected to play a left wing-back role, with Reece James on the opposite flank and Cesar Azpilicueta, Toni Rudiger and Andreas Christensen making up the back three.
Giroud leads the line with support coming from Mason Mount and Ross Barkley. Mateo Kovacic and Jorginho are the midfield two. Ruben Loftus-Cheek and Tammy Abraham are among the subs.
‘Ross has trained really well, kept his head down,' explained Lampard. 'We have got big injuries in forward areas, so there are opportunities.
'We can’t be too despondent with injuries, we have a squad for a reason, players that can come in and do their job.’
Spurs make three changes from their midweek Champions League defeat to RB Leipzig, with Jan Vertonghen, Japhet Tanganga and Tanguy Ndombele coming into the side. Dele Alli is on the bench.
Chelsea Caballero; Azpilicueta (c), Christensen, Rudiger; James, Jorginho, Kovacic, Alonso; Barkley, Mount; Giroud
Subs Kepa, Zouma, Emerson, Gilmour, Loftus-Cheek, Willian, Loftus-Cheek, Abraham
Tottenham Lloris; Alderweireld, Vertonghen, Sanchez; Davies, Winks, Lo Celso, Ndombele, Tanganga; Bergwijn, Moura
Subs Gazzaniga, Dier, Aurier, Skipp, Fernandes, Lamela, Alli
The referee is Michael Oliver.
Chelsea have won more Premier League matches against Tottenham (29) than we have against any other team in the competition.
Chelsea have only lost one (in April 2018) of our last 33 home games against Tottenham in all competitions (21 wins, 11 draws).
In the reverse fixture at Tottenham’s new stadium just before Christmas, Frank Lampard’s side won 2-0 with two first-half Willian goals, one a penalty.
The Blues are looking to achieve a league double against Tottenham for the first time since 2005/06.
Tottenham have conceded more Premier League goals against Chelsea than they have against any other team in the competition’s history (100).