There is just one change to the starting line-up from the win against Wolves and that is an enforced one.
Kurt Zouma returns to the side in place of Toni Rudiger who suffered a groin strain in Saturday’s match.
In-form Tammy Abraham will continue to lead the attack.
Cesar Azpilicueta and Willian make their 50th European appearances, becoming the seventh and eighth overseas players to reach that milestone for Chelsea.
Centre-back Marc Guehi, our development squad captain, is among the subs.
Valencia make three changes from their weekend defeat against Barcelona, all in midfield.
Chelsea Kepa; Zouma, Christensen, Tomori; Azpilicueta (c), Jorginho, Kovacic, Alonso; Willian, Abraham, Mount.
Substitutes: Caballero, Guehi, Barkley, Pulisic, Pedro, Giroud, Batshuayi.
Valencia Cillessen; Wass, Garay, Gabriel, Gaya; Coquelin, Parejo (c), Kondogbia, Cheryshev; Gameiro, Rodrigo.
Substitutes: Jaume, Jaume Costa, Diakhaby, Torres, Guedes, Lee, Gomez.
The referee is Cuneyt Cakır from Turkey.
On arrival at the Bridge, Lampard reiterated his belief that the Champions League was a special competition that could conjure memorable nights under the lights in SW6. He went on to explain his thinking behind tonight's team selection.
‘It’s a magical competition, we all feel that,' he said. 'I’ve been fortunate enough to have some big nights, and one particularly special night, in this competition as a player. There have been lots of good evenings at Stamford Bridge and I hope we can recreate some this year.
‘There are Champions League debuts for a few of the young lads so let’s see how they do. We’re competitive up front but Tammy is scoring goals and playing well – he’s confident so we go again with him.’
Chelsea are seeking to extend our 11 game unbeaten run at Stamford Bridge in European competition.
All of our past six meetings with Valencia came in the space of four-and-a-half years, four of them taking place in 2007. The Blues were 3-2 aggregate winners against Valencia in the 2006/07 Champions League quarter-finals, winning 2-1 at Mestalla after a 1-1 draw in west London; Chelsea went on to lose to Liverpool on penalties in the last four.
We also won 2-1 at Valencia in the following season's group stage before a goalless draw in London. We went on to finish first in the group with Valencia fourth, and went all the way to that season's final, losing on penalties to Manchester United in Moscow.
Chelsea's run to glory in the 2011/12 Champions League featured two games against Valencia in the group stage. Frank Lampard scored in a 1-1 draw at Mestalla on matchday two before Andre Villas-Boas’ side won 3-0 at Stamford Bridge on matchday six, our only home success against Valencia.
The Blues have scored three goals or more in five of our last nine European matches including the Super Cup. Our tally of 36 goals in last season's Europa League was one short of the competition record set by Porto in 2010/11.
Of the 21 clubs to have played at least 100 games in the Champions League, Chelsea have the fourth best goals per game ratio (1.71) behind only Real Madrid (2.13), Barcelona (2.02) and Bayern Munich (1.90).
The Blues have scored in each of our past 38 home games in European competition, netting 99 goals in the process (2.6 per game). The last occasion we failed to score was against Manchester United in the Champions League quarter-final in April 2011.