Emma Hayes makes one change from the side that started the first leg on Saturday.
With the Blues looking to overcome a 1-0 deficit in this semi-final second leg, Jessie Fleming returns to the side in place of Jelena Cankovic who is on the bench.
Ann-Katrin Berger continues in goal. Sam Kerr will once again lead the attack while it remains to be seen if she will be joined there in a pair by Guro Reiten, as in the first half of the Stamford Bridge match. Lauren James, a half-time sub on Saturday, again begins among the substitutes.
The defence is unchanged.
For Barcelona, injured Lucy Bronze is replaced by Marta Torrejon. Mariona Caldentey and Asisat Oshoala who came on last time begin up front with goalscorer Caroline Graham Hansen. Ballon d'Or winner Alexia Putellas, back from serious injury, is among their subs.
Chelsea: Berger, Mjelde, Eriksson (c), Carter, Perisset, Cuthbert, Leupolz, Charles, Fleming, Kerr, Reiten.
Subs: Musovic, Orman, Abdullina, Cankovic, Ingle, Harder, James, Rytting Kaneryd.
Barcelona: Panos, Torrejon (c), Paredes, Leon, Rolfo, Bonmati, Walsh, Guijarro, Graham Hansen, Caldentey, Oshoala
Subs: Coll, Codina Panedas, Fernandez, Pina, Crnogorcevic, Putellas, Paralluelo, Geyse, Vilamala, Rabana, Syrstad Engen, Lopez.
Referee: Esther StaubliĀ from Switzerland