Mason Mount and Tammy Abraham start for Chelsea at Old Trafford today, with N'Golo Kante and Christian Pulisic named on the bench.
It means a first senior Chelsea appearance for Mount and only a third in blue for Abraham, who made a couple of appearances for us off the bench in our final two league games of 2015/16.
Ross Barkley and Pedro are the others selected in attack, meaning Pulisic is on the bench.
Mateo Kovacic and Jorginho are expected to be the two central midfielders in front of the defence in Frank Lampard's 4-2-3-1 system. Kante has not been deemed fit enough to start, though like the American he is one of our subs at Old Trafford.
Kurt Zouma and Andreas Christensen are the centre-backs, flanked by Cesar Azpilicueta, who captains, and Emerson Palmieri. Kepa is in goal.
Speaking ahead of kick-off, Lampard said: 'We've got energy in the team and two full debuts for Chelsea for players who have come through the Academy. I like that, they need to feel like they belong here because it's not a gift - they deserve to be there.
'We're up against a good manager and a good team so a lot will come down to how the players perform in their individual battles and collectively. We've worked as hard as we can and we're confident in ourselves.'
Harry Maguire starts for Manchester United, who also name Anthony Martial, Marcus Rashford and Jesse Lingard in their side.
Chelsea are expected to line up in the following 4-2-3-1 formation:
Kepa; Azpilicueta (c), Zouma, Christensen, Emerson; Jorginho, Kovacic; Pedro, Barkley, Mount; Abraham.
Chelsea subs: Caballero, Tomori, Alonso, Kante, Pulisic, Kenedy, Giroud.
Man United are expected to line up as follows:
De Gea (c), Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Pogba, Pereira, Lingard, Rashford, Martial.
Subs: Romero, Tuanzebe, Young, Greenwood, Matic, James, Mata.
Chelsea's opening weekend record
Chelsea have only lost one (Burnley at home in 2017) of our last 20 opening weekend fixtures in the Premier League (16 wins, three draws). Our previous opening day defeat was at Highfield Road against Coventry in 1998.
Man United (18) and Chelsea (17) have won more opening weekend fixtures than any other side in the Premier League.
Chelsea and Manchester United lock horns on the opening weekend for the fifth occasion. The most recent at Stamford Bridge in 2004 was Jose Mourinho’s first match in charge of the Blues when Eidur Gudjohnsen scored the only goal. The other three were all at Old Trafford in the fifties - 1952 (lost 0-2), 1953 (drew 1-1) and 1958 (lost 2-5).
Frank Lampard's record against Man United
Frank Lampard’s playing record against United for the Blues was 11 wins, 10 draws and 10 defeats.
Lampard has a 100 per cent success rate as a manager at Old Trafford when he won there on a penalty shoot-out with Derby in last season’s Carabao Cup.
Chelsea's record at Old Trafford
Chelsea’s last victory at Old Trafford was in May 2013 when Juan Mata’s 87th-minute goal secured all three points for the Blues.
Our six Premier League victories at Old Trafford have come under six different managers: Glenn Hoddle, Ruud Gullit, Claudio Ranieri, Jose Mourinho, Carlo Ancelotti and Rafael Benitez.
Man United are unbeaten in the last six Premier League meetings at home against Chelsea, winning two and drawing four.